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KMID : 1200020190430050615
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Diabetes & Metabolism Journal
2019 Volume.43 No. 5 p.615 ~ p.626
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Association between Change in Alcohol Consumption and Metabolic Syndrome: Analysis from the Health Examinees Study
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Choi Seul-Ggie
Kim Kyu-Woong
Lee Jong-Koo
Choi Ji-Yeob
Shin Ae-Sun
Park Sue-Kyung
Kang Dae-Hee
Park Sang-Min
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Abstract
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Background: The association between change in alcohol intake and metabolic syndrome is unclear.
Methods: This retrospective cohort consisted of 41,368 males and females from the Health Examinees-GEM study. Participants were divided into non-drinkers (0.0 g/day), light drinkers (male: 0.1 to 19.9 g/day; female: 0.1 to 9.9 g/day), moderate drinkers (male: 20.0 to 39.9 g/day; female: 10.0 to 19.9 g/day), and heavy drinkers (male: ≥40.0 g/day; female: ≥20.0 g/day) for each of the initial and follow-up health examinations. Logistic regression analysis was used to determine the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for developing metabolic syndrome according to the change in alcohol consumption between the initial and follow-up health examinations. Adjusted mean values for the change in waist circumference, fasting serum glucose (FSG), blood pressure, triglycerides, and high density lipoprotein cholesterol (HDL-C) levels were determined according to the change in alcohol consumption by linear regression analysis.
Results: Compared to persistent light drinkers, those who increased alcohol intake to heavy levels had elevated risk of metabolic syndrome (aOR, 1.45; 95% CI, 1.09 to 1.92). In contrast, heavy drinkers who became light drinkers had reduced risk of metabolic syndrome (aOR, 0.61; 95% CI, 0.44 to 0.84) compared to persistent heavy drinkers. Increased alcohol consumption was associated with elevated adjusted mean values for waist circumference, FSG, blood pressure, triglycerides, and HDL-C levels (all P<0.05). Reduction in alcohol intake was associated with decreased waist circumference, FSG, blood pressure, triglycerides, and HDL-C levels among initial heavy drinkers (all P<0.05).
Conclusion: Heavy drinkers who reduce alcohol consumption could benefit from reduced risk of metabolic syndrome.
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KEYWORD
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Alcohol drinking, Dyslipidemias, Hypertension, Metabolic syndrome, Obesity
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